6eiu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6eiu is ON HOLD until Mar 19 2019
+
==Crystal structure of KDM5B in complex with KDOPZ29a==
-
 
+
<StructureSection load='6eiu' size='340' side='right' caption='[[6eiu]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
-
Authors: Srikannathasan, V., Newman, J.A., Szykowska, A., Wright, M., Ruda, G.F., Vazquez-Rodriguez, S.A., Kupinska, K., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Huber, K., von Delft, F.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6eiu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIU FirstGlance]. <br>
-
Description: Crystal structure of KDM5B in complex with KDOPZ29a
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6T:8-oxidanyl-6-phenyl-7-propan-2-yl-imidazo[1,2-b]pyridazine-3-carbonitrile'>B6T</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eiu OCA], [http://pdbe.org/6eiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eiu RCSB], [http://www.ebi.ac.uk/pdbsum/6eiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eiu ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
 +
[[Category: Bountra, C]]
 +
[[Category: Burgess-Brown, N A]]
 +
[[Category: Delft, F von]]
 +
[[Category: Edwards, A]]
[[Category: Huber, K]]
[[Category: Huber, K]]
-
[[Category: Ruda, G.F]]
+
[[Category: Kupinska, K]]
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Newman, J A]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
 +
[[Category: Ruda, G F]]
 +
[[Category: Srikannathasan, V]]
 +
[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
-
[[Category: Burgess-Brown, N.A]]
+
[[Category: Vazquez-Rodriguez, S A]]
-
[[Category: Von Delft, F]]
+
-
[[Category: Vazquez-Rodriguez, S.A]]
+
-
[[Category: Newman, J.A]]
+
-
[[Category: Edwards, A]]
+
-
[[Category: Strain-Damerell, C]]
+
[[Category: Wright, M]]
[[Category: Wright, M]]
-
[[Category: Srikannathasan, V]]
+
[[Category: Kdm5b lysine specific demethylase]]
-
[[Category: Bountra, C]]
+
[[Category: Oxidoreductase]]
-
[[Category: Kupinska, K]]
+

Revision as of 08:12, 2 May 2018

Crystal structure of KDM5B in complex with KDOPZ29a

6eiu, resolution 1.88Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6eiu"
Personal tools