6ej1

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'''Unreleased structure'''
 
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The entry 6ej1 is ON HOLD
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==Crystal structure of KDM5B in complex with KDOPZ48a.==
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<StructureSection load='6ej1' size='340' side='right' caption='[[6ej1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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Authors: Srikannathasan, V., Newman, J.A., Szykowska, A., Wright, M., Ruda, G.F., Vazquez-Rodriguez, S.A., Kupinska, K., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Huber, K., von Delft, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ej1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJ1 FirstGlance]. <br>
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Description: Crystal structure of KDM5B in complex with KDOPZ48a.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B7Q:5-[1-[1-(2-chloranylethanoyl)piperidin-4-yl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile'>B7Q</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ej1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ej1 OCA], [http://pdbe.org/6ej1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ej1 RCSB], [http://www.ebi.ac.uk/pdbsum/6ej1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ej1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A]]
[[Category: Huber, K]]
[[Category: Huber, K]]
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[[Category: Ruda, G.F]]
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[[Category: Kupinska, K]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Newman, J A]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
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[[Category: Ruda, G F]]
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[[Category: Srikannathasan, V]]
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[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
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[[Category: Burgess-Brown, N.A]]
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[[Category: Vazquez-Rodriguez, S A]]
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[[Category: Von Delft, F]]
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[[Category: Vazquez-Rodriguez, S.A]]
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[[Category: Newman, J.A]]
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[[Category: Edwards, A]]
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[[Category: Strain-Damerell, C]]
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[[Category: Wright, M]]
[[Category: Wright, M]]
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[[Category: Srikannathasan, V]]
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[[Category: Kdm5b lysine specific demethylase]]
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[[Category: Bountra, C]]
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[[Category: Oxidoreductase]]
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[[Category: Kupinska, K]]
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Revision as of 08:13, 2 May 2018

Crystal structure of KDM5B in complex with KDOPZ48a.

6ej1, resolution 2.07Å

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