Antigen 85

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The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different.
The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different.
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*<scene name='70/706736/Cv/4'>Click here to see active site</scene>.<ref>PMID:15192106</ref>
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*<scene name='70/706736/Cv/5'>Click here to see active site</scene>.<ref>PMID:15192106</ref>
</StructureSection>
</StructureSection>

Revision as of 10:43, 8 May 2018

Antigen 85C complex with detergent octylthioglucoside (PDB code 1va5)

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3D Structures of antigen 85

Updated on 08-May-2018

References

  1. Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. J Biol Chem. 2004 Aug 27;279(35):36771-7. Epub 2004 Jun 10. PMID:15192106 doi:http://dx.doi.org/10.1074/jbc.M400811200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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