5ltl
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human chemokine CCL16== | |
| - | + | <StructureSection load='5ltl' size='340' side='right' caption='[[5ltl]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ltl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LTL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltl OCA], [http://pdbe.org/5ltl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltl RCSB], [http://www.ebi.ac.uk/pdbsum/5ltl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CCL16_HUMAN CCL16_HUMAN]] Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Batra-Safferling, R]] | ||
| + | [[Category: Haenel, K]] | ||
| + | [[Category: Weiergraeber, O H]] | ||
[[Category: Willbold, D]] | [[Category: Willbold, D]] | ||
| - | [[Category: | + | [[Category: Cc-type]] |
| - | [[Category: | + | [[Category: Chemokine]] |
| - | [[Category: | + | [[Category: Chemotaxis]] |
| + | [[Category: Cytokine]] | ||
Revision as of 06:07, 9 May 2018
Structure of human chemokine CCL16
| |||||||||||
