5wnj

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m (Protected "5wnj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5wnj is ON HOLD until Paper Publication
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==Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib==
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<StructureSection load='5wnj' size='340' side='right' caption='[[5wnj]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wnj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V9:LESTAURTINIB'>2V9</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wni|5wni]], [[5wnk|5wnk]], [[5wnl|5wnl]], [[5wnm|5wnm]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnj OCA], [http://pdbe.org/5wnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnj RCSB], [http://www.ebi.ac.uk/pdbsum/5wnj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RIPK4_MOUSE RIPK4_MOUSE]] Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.<ref>PMID:12446564</ref> <ref>PMID:22197488</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Huang, C S]]
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[[Category: Hymowitz, S G]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:13, 9 May 2018

Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib

5wnj, resolution 2.55Å

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