6baq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Mus musculus BPIFA1== | |
| - | + | <StructureSection load='6baq' size='340' side='right' caption='[[6baq]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6baq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BAQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6baq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6baq OCA], [http://pdbe.org/6baq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6baq RCSB], [http://www.ebi.ac.uk/pdbsum/6baq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6baq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BPIA1_MOUSE BPIA1_MOUSE]] Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.<ref>PMID:23499554</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Little, M S]] | ||
| + | [[Category: Redinbo, M R]] | ||
| + | [[Category: Antimicrobial protein]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Lung defense protein]] | ||
| + | [[Category: Surfactant protein]] | ||
Revision as of 06:15, 9 May 2018
Mus musculus BPIFA1
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