6cev
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==MBD3 MBD in complex with methylated, non-palindromic CpG DNA: alternative interpretation of crystallographic data== | |
| - | + | <StructureSection load='6cev' size='340' side='right' caption='[[6cev]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cev]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CEV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ceu|6ceu]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cev OCA], [http://pdbe.org/6cev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cev RCSB], [http://www.ebi.ac.uk/pdbsum/6cev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cev ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN]] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Liu, K]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | + | [[Category: Structural genomic]] | |
| - | + | ||
| - | [[Category: Structural | + | |
| - | + | ||
| - | + | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| + | [[Category: Wernimont, A K]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transcription-dna complex]] | ||
Revision as of 06:17, 9 May 2018
MBD3 MBD in complex with methylated, non-palindromic CpG DNA: alternative interpretation of crystallographic data
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