2hyi
From Proteopedia
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|PDB= 2hyi |SIZE=350|CAPTION= <scene name='initialview01'>2hyi</scene>, resolution 2.3Å | |PDB= 2hyi |SIZE=350|CAPTION= <scene name='initialview01'>2hyi</scene>, resolution 2.3Å | ||
|SITE= | |SITE= | ||
- | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MAGOH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RBM8A, RBM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), DDX48, EIF4A3, KIAA0111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CASC3, MLN51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MAGOH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RBM8A, RBM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), DDX48, EIF4A3, KIAA0111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CASC3, MLN51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
+ | |DOMAIN= | ||
+ | |RELATEDENTRY=[[2hxy|2hxy]], [[1p27|1p27]], [[2db3|2db3]] | ||
+ | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hyi OCA], [http://www.ebi.ac.uk/pdbsum/2hyi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hyi RCSB]</span> | ||
}} | }} | ||
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[[Category: Andersen, G R.]] | [[Category: Andersen, G R.]] | ||
[[Category: Hir, H Le.]] | [[Category: Hir, H Le.]] | ||
- | [[Category: ANP]] | ||
- | [[Category: MG]] | ||
[[Category: dead-box atpase]] | [[Category: dead-box atpase]] | ||
[[Category: exon junction]] | [[Category: exon junction]] | ||
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[[Category: translation]] | [[Category: translation]] | ||
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:37:13 2008'' |
Revision as of 00:37, 31 March 2008
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, resolution 2.3Å | |||||||
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Ligands: | , , | ||||||
Gene: | MAGOH (Homo sapiens), RBM8A, RBM8 (Homo sapiens), DDX48, EIF4A3, KIAA0111 (Homo sapiens), CASC3, MLN51 (Homo sapiens) | ||||||
Related: | 2hxy, 1p27, 2db3
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Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
Coordinates: | save as pdb, mmCIF, xml |
Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA
Overview
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.
About this Structure
2HYI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA., Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Seraphin B, Le Hir H, Andersen GR, Science. 2006 Sep 29;313(5795):1968-72. Epub 2006 Aug 24. PMID:16931718
Page seeded by OCA on Mon Mar 31 03:37:13 2008