5uqz
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqz OCA], [http://pdbe.org/5uqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uqz RCSB], [http://www.ebi.ac.uk/pdbsum/5uqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqz OCA], [http://pdbe.org/5uqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uqz RCSB], [http://www.ebi.ac.uk/pdbsum/5uqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The high-resolution structure of Glucan binding protein C (GbpC) at 1.14 A, a sucrose-dependent virulence factor of the dental caries pathogen Streptococcus mutans, has been determined. GbpC not only shares structural similarities with the V-regions of AgI/II and SspB, but also functional adherence to SAG and its scavenger receptor cysteine rich domains (SRCRs) which is not only a newly identified function for GbpC, but also an additional fail-safe binding mechanism for S. mutans Despite the structural similarities with S. mutans Antigen I/II (AgI/II) and SspB of Streptococcus gordonii, GbpC remains unique among these surface proteins in its propensity to adhere to dextran/glucans. The complex crystal structure of GbpC with dextrose (beta-D glucose, BGC) highlights exclusive structural features that facilitates this interaction with dextran. Targeted deletion mutant studies on GbpC's divergent loop region in the vicinity of a highly-conserved calcium binding site confirm its role in biofilm formation. Finally, we present a model for adherence to dextran. The structure of GbpC highlights how artfully microbes have engineered the lectin-like folds to broaden their functional adherence repertoire. | ||
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| + | Glucan Binding Protein C of Streptococcus mutans Mediates both Sucrose-Independent and Sucrose-Dependent Adherence.,Mieher JL, Larson MR, Schormann N, Purushotham S, Wu R, Rajashankar KR, Wu H, Deivanayagam C Infect Immun. 2018 Apr 23. pii: IAI.00146-18. doi: 10.1128/IAI.00146-18. PMID:29685986<ref>PMID:29685986</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5uqz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:27, 9 May 2018
Structural Analysis of the Glucan Binding Protein C of Streptococcus mutans Provides Evidence that it Mediates both Sucrose-Independent and -Dependent Adherence
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