Dual specificity protein kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*CLK1
+
*CLK1 kinase domain
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**[[1z57]] – hCLK1 kinase domain + himenialdizine – human
+
**[[1z57]] – hCLK1 + himenialdizine – human
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**[[2vag]] - hCLK1 kinase domain + indole inhibitor<br />
+
**[[5j1v]], [[5j1w]], [[2vag]], [[5x8i]] – hCLK1 + inhibitor<br />
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**[[5j1v]], [[5j1w]] – hCLK1 kinase domain + quinazoline inhibitor<br />
+
**[[6g33]] – hCLK1 + iodotubercidine inhibitor<br />
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*CLK2
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*CLK2 kinase domain
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**[[3nr9]] – hCLK2 kinase domain
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**[[3nr9]] – hCLK2<br />
 +
**[[5unp]] – hCLK2 + inhibitor<br />
*CLK3
*CLK3
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*TTK
*TTK
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**[[3cek]], [[3dbq]] – hTTK kinase domain<br />
+
**[[3cek]], [[3dbq]], [[2zmc]] – hTTK kinase domain<br />
**[[4b94]], [[4h7x]], [[4h7y]] - hTTK TPR domain<br />
**[[4b94]], [[4h7x]], [[4h7y]] - hTTK TPR domain<br />
**[[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand
**[[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand
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**[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
**[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
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**[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]], [[4js8]], [[4jt3]], [[3wzj]], [[3wzk]], [[4o6l]], [[5ehl]], [[5eho]], [[5ehy]], [[5ei2]], [[5ei6]], [[5ei8]], [[5ap0]], [[5ap1]], [[5ap2]], [[5eh0]], [[4zeg]] - hTTK kinase domain + inhibitor
+
**[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]], [[4js8]], [[4jt3]], [[3wzj]], [[3wzk]], [[4o6l]], [[5ehl]], [[5eho]], [[5ehy]], [[5ei2]], [[5ei6]], [[5ei8]], [[5ap0]], [[5ap1]], [[5ap2]], [[5eh0]], [[4zeg]], [[6b4w]], [[5na0]], [[5n9s]], [[5n93]], [[5n87]], [[5n84]], [[5n7v]] - hTTK kinase domain + inhibitor
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**[[2zmc]] - hTTK kinase domain
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**[[2zmd]], [[5ap3]], [[5ap4]], [[5ap5]], [[5ap6]], [[5ap7]], [[5o91]], [[5ntt]], [[5nad]], [[5mrb]] - hTTK kinase domain (mutant) + inhibitor<br />
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+
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**[[2zmd]], [[5ap3]], [[5ap4]], [[5ap5]], [[5ap6]], [[5ap7]] - hTTK kinase domain (mutant) + inhibitor<br />
+
**[[3hmn]] - hTTK kinase domain + ATP
**[[3hmn]] - hTTK kinase domain + ATP

Revision as of 09:27, 9 May 2018

Dual specificity protein kinase TTK kinase domain complex with inhibitor, 2x9e

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3D structures of dual specificity protein kinase

Updated on 09-May-2018

References

  1. ↑ Dhanasekaran N, Premkumar Reddy E. Signaling by dual specificity kinases. Oncogene. 1998 Sep 17;17(11 Reviews):1447-55. PMID:9779990 doi:http://dx.doi.org/10.1038/sj.onc.1202251
  2. ↑ Colombo R, Caldarelli M, Mennecozzi M, Giorgini ML, Sola F, Cappella P, Perrera C, Depaolini SR, Rusconi L, Cucchi U, Avanzi N, Bertrand JA, Bossi RT, Pesenti E, Galvani A, Isacchi A, Colotta F, Donati D, Moll J. Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. PMID:21159646 doi:10.1158/0008-5472.CAN-10-2101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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