DXP reductoisomerase
From Proteopedia
(Difference between revisions)
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**[[4zn6]] – DXR – ''Acinetobacter baumannii'' <br /> | **[[4zn6]] – DXR – ''Acinetobacter baumannii'' <br /> | ||
**[[4zqe]] – McDXR – ''Moraxella catarrhalis''<br /> | **[[4zqe]] – McDXR – ''Moraxella catarrhalis''<br /> | ||
| + | **[[5kqo]], [[5kry]], [[5ks1]] – VvDXR – ''Vibrio vulnificus''<br /> | ||
*DXP reductoisomerase binary complex | *DXP reductoisomerase binary complex | ||
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**[[1t1r]], [[1t1s]] – EcDXR + bisphosphonate<br /> | **[[1t1r]], [[1t1s]] – EcDXR + bisphosphonate<br /> | ||
**[[1jvs]] – EcDXR + NADPH<br /> | **[[1jvs]] – EcDXR + NADPH<br /> | ||
| - | ** | + | **[[1r0l]] – ZmDXR + NADPH<br /> |
**[[2jd1]] – MtDXR + NADPH<br /> | **[[2jd1]] – MtDXR + NADPH<br /> | ||
**[[2jd0]] – MtDXR (mutant) + NADPH<br /> | **[[2jd0]] – MtDXR (mutant) + NADPH<br /> | ||
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**[[3iie]] – YpDXR + Mg – ''Yersinia pestis''<br /> | **[[3iie]] – YpDXR + Mg – ''Yersinia pestis''<br /> | ||
**[[5dul]] – YpDXR + NADPH<br /> | **[[5dul]] – YpDXR + NADPH<br /> | ||
| + | **[[5krr]] – VvDXR + Mn<br /> | ||
| + | **[[5krv]] – VvDXR + Arg<br /> | ||
*DXP reductoisomerase ternary complex | *DXP reductoisomerase ternary complex | ||
Revision as of 09:52, 9 May 2018
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3D Structures of DXP reductoisomerase
Updated on 09-May-2018
References
- ↑ Takahashi S, Kuzuyama T, Watanabe H, Seto H. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9879-84. PMID:9707569
- ↑ Jansson AM, Wieckowska A, Bjorkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlen A, Mowbray SL. DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17. PMID:23819803 doi:http://dx.doi.org/10.1021/jm4006498
