5ncn

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'''Unreleased structure'''
 
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The entry 5ncn is ON HOLD until Paper Publication
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==Crystal structure Dbf2(NTR)-Mob1 complex==
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<StructureSection load='5ncn' size='340' side='right' caption='[[5ncn]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Gogl, G., Remenyi, A., Parker, B., Weiss, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ncn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NCN FirstGlance]. <br>
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Description: Crystal structure Dbf2(NTR)-Mob1 complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Weiss, E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ncn OCA], [http://pdbe.org/5ncn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ncn RCSB], [http://www.ebi.ac.uk/pdbsum/5ncn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ncn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MOB1_YEAST MOB1_YEAST]] Functions as an activator subunit for the DBF2 protein kinase. Binds to DBF2, which is required for the phosphorylation and activation of DBF2 by the upstream kinase CDC15 in late anaphase. DBF2-MOB1 is part of the mitotic exit network (MEN) signaling cascade, which regulates release from the nucleus and activity of phosphatase CDC14. Required for inactivation of mitotic cyclin-dependent kinase for exit from mitosis, cytokinesis and G1 gene transcription.<ref>PMID:11564880</ref> <ref>PMID:11404483</ref> <ref>PMID:16176976</ref> [[http://www.uniprot.org/uniprot/DBF2_YEAST DBF2_YEAST]] Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Phosphorylates CHS2 to regulate its dynamics and chitin synthesis at the division site during cytokinesis. Coordinates septin and actomyosin ring (AMR) functions during cytokinesis through the phosphorylation of HOF1. In complex with MOB1, phosphorylates CDC14 at sites adjacent to its nuclear localization sequence, thereby retaining CDC14 in the cytoplasm. Binds also to SWI5 and CLB2 mRNAs cotranscriptionally to regulate their decay. In the nucleus, the DBF2-MOB1 complex regulates passenger protein localization during anaphase. Mediates sorbic acid stress tolerance through promoting vacuolar H(+)-ATPase function, probably through phosphorylation of VMA1 and VMA2 subunits.<ref>PMID:10228157</ref> <ref>PMID:10984431</ref> <ref>PMID:11378390</ref> <ref>PMID:11404483</ref> <ref>PMID:11598184</ref> <ref>PMID:12832486</ref> <ref>PMID:14551257</ref> <ref>PMID:16176976</ref> <ref>PMID:16242037</ref> <ref>PMID:18048916</ref> <ref>PMID:19221193</ref> <ref>PMID:20123997</ref> <ref>PMID:20442249</ref> <ref>PMID:22196726</ref> <ref>PMID:22573892</ref> <ref>PMID:23447700</ref> <ref>PMID:8131744</ref> <ref>PMID:9528782</ref> <ref>PMID:9613578</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Gogl, G]]
[[Category: Gogl, G]]
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[[Category: Parker, B]]
[[Category: Remenyi, A]]
[[Category: Remenyi, A]]
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[[Category: Parker, B]]
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[[Category: Weiss, E]]
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[[Category: Kinase]]
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[[Category: Signaling protein]]

Revision as of 05:17, 16 May 2018

Crystal structure Dbf2(NTR)-Mob1 complex

5ncn, resolution 3.50Å

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