5ncl
From Proteopedia
(Difference between revisions)
m (Protected "5ncl" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Cbk1-Mob2 kinase-coactivator complex with an SSD1 peptide== | |
| - | + | <StructureSection load='5ncl' size='340' side='right' caption='[[5ncl]], [[Resolution|resolution]] 3.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ncl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NCL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ncl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ncl OCA], [http://pdbe.org/5ncl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ncl RCSB], [http://www.ebi.ac.uk/pdbsum/5ncl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ncl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CBK1_YEAST CBK1_YEAST]] Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation. [[http://www.uniprot.org/uniprot/SSD1_YEAST SSD1_YEAST]] Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase. [[http://www.uniprot.org/uniprot/MOB2_YEAST MOB2_YEAST]] Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.<ref>PMID:11747810</ref> <ref>PMID:12196508</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Gogl, G]] | [[Category: Gogl, G]] | ||
| + | [[Category: Parker, B]] | ||
[[Category: Remenyi, A]] | [[Category: Remenyi, A]] | ||
| - | [[Category: | + | [[Category: Weiss, E]] |
| + | [[Category: Kinase]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 05:18, 16 May 2018
Crystal structure of the Cbk1-Mob2 kinase-coactivator complex with an SSD1 peptide
| |||||||||||
