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5vql
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide== | |
| - | + | <StructureSection load='5vql' size='340' side='right' caption='[[5vql]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VQL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vb3|5vb3]], [[5vb5|5vb5]], [[5vb6|5vb6]], [[5vb7|5vb7]], [[5vqk|5vqk]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [http://pdbe.org/5vql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [http://www.ebi.ac.uk/pdbsum/5vql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Li, X]] | ||
| + | [[Category: Nuclear hormone receptor]] | ||
| + | [[Category: Nuclear receptor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 05:24, 16 May 2018
X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide
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