6c0b
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B== | |
| - | + | <StructureSection load='6c0b' size='340' side='right' caption='[[6c0b]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c0b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C0B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0b OCA], [http://pdbe.org/6c0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c0b RCSB], [http://www.ebi.ac.uk/pdbsum/6c0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0b ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD2_HUMAN FZD2_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, P]] | ||
| + | [[Category: Jin, R]] | ||
| + | [[Category: Lam, K]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 05:29, 16 May 2018
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
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