6fnw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a volume-regulated anion channel of the LRRC8A family== | |
| - | + | <StructureSection load='6fnw' size='340' side='right' caption='[[6fnw]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6fnw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnw OCA], [http://pdbe.org/6fnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnw RCSB], [http://www.ebi.ac.uk/pdbsum/6fnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnw ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Deneka, D]] | ||
| + | [[Category: Dutzler, R]] | ||
| + | [[Category: Lam, A K.M]] | ||
| + | [[Category: Paulino, C]] | ||
| + | [[Category: Sawicka, M]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Leucine-rich repeat domain]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 05:36, 16 May 2018
Structure of a volume-regulated anion channel of the LRRC8A family
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