2i6z
From Proteopedia
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|PDB= 2i6z |SIZE=350|CAPTION= <scene name='initialview01'>2i6z</scene>, resolution 1.90Å | |PDB= 2i6z |SIZE=350|CAPTION= <scene name='initialview01'>2i6z</scene>, resolution 1.90Å | ||
|SITE= <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene> | |SITE= <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CPT:CIS-PLATINUM-(NH3)2'>CPT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6z OCA], [http://www.ebi.ac.uk/pdbsum/2i6z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i6z RCSB]</span> | ||
}} | }} | ||
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[[Category: Messori, L.]] | [[Category: Messori, L.]] | ||
[[Category: Temperini, C.]] | [[Category: Temperini, C.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: CPT]] | ||
| - | [[Category: DMS]] | ||
[[Category: anticancer drug]] | [[Category: anticancer drug]] | ||
[[Category: cisplatin-lysozyme adduct]] | [[Category: cisplatin-lysozyme adduct]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:34 2008'' |
Revision as of 00:40, 31 March 2008
| |||||||
| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , and | ||||||
| Ligands: | , , | ||||||
| Activity: | Lysozyme, with EC number 3.2.1.17 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
Overview
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.
About this Structure
2I6Z is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231
Page seeded by OCA on Mon Mar 31 03:40:34 2008
