6g9o
From Proteopedia
(Difference between revisions)
m (Protected "6g9o" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution== | |
| - | + | <StructureSection load='6g9o' size='340' side='right' caption='[[6g9o]], [[Resolution|resolution]] 4.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g9o]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G9O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g8z|6g8z]], [[6g9l|6g9l]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9o OCA], [http://pdbe.org/6g9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g9o RCSB], [http://www.ebi.ac.uk/pdbsum/6g9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9o ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Deneka, D]] | ||
| + | [[Category: Dutzler, R]] | ||
| + | [[Category: Lam, A K.M]] | ||
| + | [[Category: Paulino, C]] | ||
| + | [[Category: Sawicka, M]] | ||
| + | [[Category: Chloride channel]] | ||
| + | [[Category: Leucine-rich repeat]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Swelling-activated]] | ||
| + | [[Category: Vsoac]] | ||
Revision as of 05:39, 16 May 2018
Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution
| |||||||||||
