4ykb
From Proteopedia
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<StructureSection load='4ykb' size='340' side='right' caption='[[4ykb]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='4ykb' size='340' side='right' caption='[[4ykb]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ykb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKB FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4ykb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKB FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ykb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykb OCA], [http://pdbe.org/4ykb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ykb RCSB], [http://www.ebi.ac.uk/pdbsum/4ykb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ykb ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GUN4, CHLREDRAFT_205768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ykb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykb OCA], [http://pdbe.org/4ykb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ykb RCSB], [http://www.ebi.ac.uk/pdbsum/4ykb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ykb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The genomes uncoupled 4 (GUN4) protein stimulates chlorophyll biosynthesis by increasing the activity of Mg-chelatase, the enzyme that inserts magnesium into protoporphyrin IX (PPIX) in the chlorophyll biosynthesis pathway. One of the roles of GUN4 is in binding PPIX and Mg-PPIX. In eukaryotes, GUN4 also participates in plastid-to-nucleus signalling, although the mechanism for this is unclear. Here, the first crystal structure of a eukaryotic GUN4, from Chlamydomonas reinhardtii, is presented. The structure is in broad agreement with those of previously solved cyanobacterial structures. Most interestingly, conformational divergence is restricted to several loops which cover the porphyrin-binding cleft. The conformational dynamics suggested by this ensemble of structures lend support to the understanding of how GUN4 binds PPIX or Mg-PPIX. | ||
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| + | Structure of GUN4 from Chlamydomonas reinhardtii.,Tarahi Tabrizi S, Langley DB, Harrop SJ, Duff AP, Willows RD Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1094-9. doi:, 10.1107/S2053230X15012248. Epub 2015 Jul 29. PMID:26249706<ref>PMID:26249706</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4ykb" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Chlre]] | ||
[[Category: Duff, A P]] | [[Category: Duff, A P]] | ||
[[Category: Harrop, S J]] | [[Category: Harrop, S J]] | ||
Revision as of 05:44, 16 May 2018
Structure of GUN4 from Chlamydomonas reinhardtii
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