2bzs
From Proteopedia
(Difference between revisions)
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| - | == | + | |
| + | ==Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.== | ||
<StructureSection load='2bzs' size='340' side='right' caption='[[2bzs]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2bzs' size='340' side='right' caption='[[2bzs]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qr2|1qr2]], [[1sg0|1sg0]], [[1zx1|1zx1]], [[2qr2|2qr2]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qr2|1qr2]], [[1sg0|1sg0]], [[1zx1|1zx1]], [[2qr2|2qr2]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzs OCA], [http://pdbe.org/2bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bzs RCSB], [http://www.ebi.ac.uk/pdbsum/2bzs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzs OCA], [http://pdbe.org/2bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bzs RCSB], [http://www.ebi.ac.uk/pdbsum/2bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzs ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzs_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Nqo2]] | [[Category: Nqo2]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
| + | [[Category: Polymorphism]] | ||
| + | [[Category: Zinc]] | ||
Revision as of 06:11, 16 May 2018
Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.
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Categories: Human | Doughty, S W | Heap, J T | Kellam, B | Khader, M M.Abu | Matteis, C De | Minton, N | Paoli, M | Cb1954 | Fad | Flavoprotein | Metal-binding | Nqo2 | Oxidoreductase | Polymorphism | Zinc
