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Ephrin receptor

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Line 30: Line 30:
**[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR />
**[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR />
*Ephrin A2 receptor
*Ephrin A2 receptor
-
**[[3hpn]], [[3c8x]] - hEPHR A2 LBD<BR />
+
**[[3hpn]], [[3c8x]] - hEPHR A2 LBD residues 28-201<BR />
-
**[[2x10]], [[3fl7]] - hEPHR A2 ectodomain<BR />
+
**[[2x10]], [[3fl7]] - hEPHR A2 ectodomain residues 27-435<BR />
**[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR />
**[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR />
-
**[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]], [[5ek7]], [[5i9u]] - hEPHR A2 kinase domain<BR />
+
**[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]], [[5ek7]], [[5i9u]] - hEPHR A2 kinase domain residues 596-900<BR />
*''Ephrin A2 receptor binary complex''<br />
*''Ephrin A2 receptor binary complex''<br />
Line 40: Line 40:
**[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR />
**[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR />
**[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
**[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
-
**[[2kso]] - hEPHR A2 SAM + SHIP2<br />
+
**[[2kso]] - hEPHR A2 SAM fragment residues 945-969 + SHIP2<br />
-
**[[5i9v]], [[5i9w]] - hEPHR A2 kinase domain + inhibitor<br />
+
**[[5nz9]] - hEPHR A2 SAM fragment<br />
 +
**[[5i9v]], [[5i9w]], [[5njz]], [[5nk0]], [[5nk1]], [[5nk2]], [[5nk3]], [[5nk4]], [[5nk5]], [[5nk6]], [[5nk7]], [[5nk8]], [[5nk9]], [[5nka]], [[5nkb]], [[5nkc]], [[5nkd]], [[5nke]], [[5nkf]], [[5nkg]], [[5nkh]], [[5nki]] - hEPHR A2 kinase domain + inhibitor<br />
**[[5i9x]], [[5i9y]], [[5i9z]], [[5ia0]], [[5ia1]], [[5ia2]], [[5ia3]], [[5ia4]], [[5ia5]] - hEPHR A2 kinase domain + kinase drug<br />
**[[5i9x]], [[5i9y]], [[5i9z]], [[5ia0]], [[5ia1]], [[5ia2]], [[5ia3]], [[5ia4]], [[5ia5]] - hEPHR A2 kinase domain + kinase drug<br />
Line 93: Line 94:
**[[2eao]] – hEPHR B1 SAM – NMR<BR />
**[[2eao]] – hEPHR B1 SAM – NMR<BR />
**[[2djs]] - hEPHR B1 fn3 domain – NMR<BR />
**[[2djs]] - hEPHR B1 fn3 domain – NMR<BR />
-
**[[3zfx]] - hEPHR B1 kinase domain<br />
+
**[[3zfx]] - hEPHR B1 kinase domain residues 602-896<br />
 +
**[[5mja]] - hEPHR B1 kinase domain + inhibitor<br />
 +
**[[5mjb]] - hEPHR B1 kinase domain (mutant) + inhibitor<br />
*Ephrin B2 receptor
*Ephrin B2 receptor

Revision as of 08:43, 16 May 2018

Human ephrin A3 receptor (magenta) complex with peptide substrate (green), nucleotide derivative and Mg+2 ion 3fxx

Drag the structure with the mouse to rotate

3D Structures of ephrin receptors

Updated on 16-May-2018


References

  1. ↑ Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
  2. ↑ Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
  3. ↑ Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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