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Eukaryotic initiation factor

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Line 24: Line 24:
**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
-
**[[2ogh]] - yEIF1 – NMR<BR />
+
**[[2ogh]] - yEIF1 – yeast - NMR<BR />
-
**[[3j80]], [[3j81]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
+
**[[3j80]], [[3j81]], [[4uer]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
Line 31: Line 31:
*EIF2
*EIF2
-
**[[1kl9]], [[1q8k]] – hEIF2A subunit 1<BR />
+
**[[1kl9]], [[1q8k]], [[5oa9]] – hEIF2A subunit 1<BR />
-
**[[1q8x ]]– hEIF2A - NMR<BR />
+
**[[1q8x]] – hEIF2A - NMR<BR />
-
**[[1si2]], [[1si3]], [[4olb]], [[4f3t]] – hEIF2C PAZ domain + DNA<BR />
+
**[[6ezo]] – hEIF2B + drug <br />
-
**[[3luk]] - hEIF2C MID domain <BR />
+
**[[5w2f]] – hEIF2D C-terminal <br />
-
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C MID domain + nucleotide<br />
+
**[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br />
**[[1q46]] – yEIF2A – yeast<BR />
**[[1q46]] – yEIF2A – yeast<BR />
**[[3wj9]] - EIF2A – fission yeast<br />
**[[3wj9]] - EIF2A – fission yeast<br />
Line 41: Line 41:
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[3ecs]] – hEIF2B
**[[3ecs]] – hEIF2B
 +
 +
*EIF2C or argonaute
 +
 +
**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br />
 +
**[[5w6v]] – hEI2C1 + RNA + GW182<br />
 +
**[[3luk]] – hEI2C2 mid domain<br />
 +
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C mid domain + nucleotide<br />
 +
**[[5t7b]], [[5ki6]], [[4f3t]] – hEI2C2 + RNA<br />
 +
**[[4z4i]], [[4z4h]], [[4z4g]], [[4z4f]], [[4z4e]], [[4z4d]], [[4z4c]], [[4w5t]], [[4w5r]], [[4w5q]], [[4w5o]], [[4w5n]], [[4ola]], [[6cbd]], [[5wea]], [[5js2]], [[5js1]], [[4ei3]] – hEI2C2 (mutant) + RNA<br />
 +
**[[5vm9]] – hEI2C3 + RNA<br />
*EIF3
*EIF3
Line 48: Line 58:
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
**[[4u1f]] - yEIF3B middle domain<br />
**[[4u1f]] - yEIF3B middle domain<br />
 +
**[[5h7u]] - yEIF3C residues 36-163<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
**[[5k1h]] – hEIF3B + EIF3A C-terminal<br />
**[[5k1h]] – hEIF3B + EIF3A C-terminal<br />
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
-
**[[5krb]], [[5krc]], [[5krd]] – EIF3D – wasp<br />
+
**[[5krb]], [[5krc]], [[5krd]], [[5k4d]], [[5k4c]], [[5k4b]] – EIF3D – wasp<br />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2mjc]] - hEIF3G residues 153-176 – NMR<br />
**[[2mjc]] - hEIF3G residues 153-176 – NMR<br />
 +
**[[5k0y]] - rEIF3G in ribosome – cryo EM<br />
**[[3zwl]] - yEIF3I + EIF3B CTD<BR />
**[[3zwl]] - yEIF3I + EIF3B CTD<BR />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
Line 72: Line 84:
**[[5gw6]] – hEIF4E (mutant)<br />
**[[5gw6]] – hEIF4E (mutant)<br />
**[[2wmc]] - EIF4E - pea<BR />
**[[2wmc]] - EIF4E - pea<BR />
 +
**[[5me7]] - mmEIF4E - muskmelon<br />
**[[2idr]] – wEIF4E – wheat<BR />
**[[2idr]] – wEIF4E – wheat<BR />
**[[3l6a]] - hEIF4GII CTD<BR />
**[[3l6a]] - hEIF4GII CTD<BR />
Line 83: Line 96:
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
**[[4c9b]] - hEIF4A + CWC22<br />
**[[4c9b]] - hEIF4A + CWC22<br />
 +
**[[5mqf]] - hEIF4A in splicesome – Cryo EM<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
Line 88: Line 102:
**[[4bea]] - hEIF4E + stapled peptide<br />
**[[4bea]] - hEIF4E + stapled peptide<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
 +
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
 +
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
Line 97: Line 113:
**[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br />
**[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br />
**[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br />
**[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br />
 +
**[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]] - mEIF4E + mRNA cap analog<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR />
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR />
Line 108: Line 125:
**[[4ue9]] - DmEIF4E + 4E transporter <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
**[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br />
**[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br />
 +
**[[5me6]] - mmEIF4E + GDP derivative<br />
 +
**[[5me5]] - mmEIF4E + EIF4GI<br />
*EIF5
*EIF5
Line 135: Line 154:
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
**[[5m3q]] – CtEIF6 <br />
**[[5m3q]] – CtEIF6 <br />
 +
**[[5anb]], [[5an9]] – EIF6 in 60S ribosome – slime mold – cryo EM<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:51, 17 May 2018

Human initiation factor EIF4E complex with 7-methyl GPPPA 1ipb

Drag the structure with the mouse to rotate

3D structures of eukaryotic initiation factor

Updated on 17-May-2018

References

  1. ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
  2. ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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