1w8k
From Proteopedia
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Revision as of 15:23, 5 November 2007
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CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX
Overview
Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine, candidate. The protein is essential for host-cell invasion, but its, molecular function is unknown. The crystal structure of the three domains, comprising the ectoplasmic region of the antigen from P. vivax, solved at, 1.8 angstrom resolution, shows that domains I and II belong to the PAN, motif, which defines a superfamily of protein folds implicated in receptor, binding. We also mapped the epitope of an invasion-inhibitory monoclonal, antibody specific for the P. falciparum ortholog and modeled this to the, structure. The location of the epitope and current knowledge on, structure-function correlations for PAN domains together suggest a, receptor-binding role during invasion in which domain II plays a critical, part. These results are likely to aid vaccine and drug design.
About this Structure
1W8K is a Single protein structure of sequence from Plasmodium vivax with IMD as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure of the malaria vaccine candidate apical membrane antigen 1., Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA, Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:15731407
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