Farnesyl diphosphate synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 49: Line 49:
**[[5hxp]] – z,z-FPS (mutant) + IPP<br />
**[[5hxp]] – z,z-FPS (mutant) + IPP<br />
**[[5hxq]] – z,z-FPS (mutant) + DMSPP<br />
**[[5hxq]] – z,z-FPS (mutant) + DMSPP<br />
 +
**[[6b07]], [[6b02]], [[6b04]], [[6b06]] – FPS + inhibitor – spruce budworm moth<br />
*FPS ternary complexes
*FPS ternary complexes

Revision as of 06:47, 23 May 2018

Human farnesyl diphosphate synthase complex with lipophylic bisphosphonate inhibitor and Mg+2 ions (green) (PDB code 2opm)

Drag the structure with the mouse to rotate

3D structures of farnesyl diphosphate synthase

Updated on 23-May-2018

References

  1. ↑ Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J Biol Chem. 2001 Apr 13;276(15):11624-30. Epub 2001 Jan 4. PMID:11152452 doi:http://dx.doi.org/10.1074/jbc.M007168200
  2. ↑ Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochim Biophys Acta. 2014 Apr 4;1841(4):569-73. doi:, 10.1016/j.bbalip.2013.12.010. Epub 2013 Dec 22. PMID:24369118 doi:http://dx.doi.org/10.1016/j.bbalip.2013.12.010
  3. ↑ Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc. 2009 Apr 15;131(14):5153-62. PMID:19309137 doi:10.1021/ja808285e
Retrieved from "http://52.214.119.220/wiki/index.php/Farnesyl_diphosphate_synthase"
Personal tools