6dcn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Bcl-xL complex with Beclin 1 BH3 domain T108pThr== | |
| - | + | <StructureSection load='6dcn' size='340' side='right' caption='[[6dcn]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dcn]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5vb1 5vb1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DCN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vax|5vax]], [[5vau|5vau]], [[5vay|5vay]]</td></tr> |
| - | [[Category: Fairlie, W | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dcn OCA], [http://pdbe.org/6dcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dcn RCSB], [http://www.ebi.ac.uk/pdbsum/6dcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dcn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fairlie, W D]] | ||
| + | [[Category: Lee, E F]] | ||
| + | [[Category: Smith, B J]] | ||
| + | [[Category: Smith, N A]] | ||
[[Category: Yao, S]] | [[Category: Yao, S]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Autophagy]] |
| - | [[Category: | + | [[Category: Bcl-2]] |
| + | [[Category: Beclin 1]] | ||
Revision as of 07:09, 23 May 2018
Bcl-xL complex with Beclin 1 BH3 domain T108pThr
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Categories: Fairlie, W D | Lee, E F | Smith, B J | Smith, N A | Yao, S | Apoptosis | Autophagy | Bcl-2 | Beclin 1
