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5vt8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mouse Cadherin-23 EC24-25== | |
| - | + | <StructureSection load='5vt8' size='340' side='right' caption='[[5vt8]], [[Resolution|resolution]] 2.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vt8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VT8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vt8 OCA], [http://pdbe.org/5vt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vt8 RCSB], [http://www.ebi.ac.uk/pdbsum/5vt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vt8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jaiganesh, A]] | ||
| + | [[Category: Sotomayor, M]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Calcium-binding protein]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Hearing]] | ||
| + | [[Category: Mechanotransduction]] | ||
Revision as of 07:14, 23 May 2018
Crystal Structure of Mouse Cadherin-23 EC24-25
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