We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
5ydm
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of the Acyl Transferase domain of SpnD complex with benzylmalonyl== |
| + | <StructureSection load='5ydm' size='340' side='right' caption='[[5ydm]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ydm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YDM FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUW:(2R)-2-methanoyl-3-phenyl-propanoic+acid'>DUW</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ydm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ydm OCA], [http://pdbe.org/5ydm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ydm RCSB], [http://www.ebi.ac.uk/pdbsum/5ydm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ydm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Polyketides are a large family of pharmaceutically important natural products, and the structural modification of their scaffolds is significant for drug development. Herein, we report high-resolution X-ray crystal structures of the broadly selective acyltransferase (AT) from the splenocin polyketide synthase (SpnD-AT) in the apo form and in complex with benzylmalonyl and pentynylmalonyl extender unit mimics. These structures revealed the molecular basis for the stereoselectivity and substrate specificity of SpnD-AT, and enabled the engineering of the industrially important Ery-AT6 to broaden its substrate scope to include three new types of extender units. | ||
| - | + | Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.,Li Y, Zhang W, Zhang H, Tian W, Wu L, Wang S, Zheng M, Zhang J, Sun C, Deng Z, Sun Y, Qu X, Zhou J Angew Chem Int Ed Engl. 2018 May 14;57(20):5823-5827. doi:, 10.1002/anie.201802805. Epub 2018 Apr 14. PMID:29536601<ref>PMID:29536601</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5ydm" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
| - | [[Category: Zhou, J | + | [[Category: Qu, X D]] |
| + | [[Category: Zhou, J H]] | ||
| + | [[Category: Acyl transferase domain]] | ||
| + | [[Category: Pk]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:17, 23 May 2018
The crystal structure of the Acyl Transferase domain of SpnD complex with benzylmalonyl
| |||||||||||
Categories: Li, Y | Qu, X D | Zhou, J H | Acyl transferase domain | Pk | Transferase
