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5ygy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide== | |
| - | + | <StructureSection load='5ygy' size='340' side='right' caption='[[5ygy]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ygy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YGY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0B6:~{N}-[3-[(4~{S})-2-azanyl-6-(fluoranylmethyl)-4-methyl-1,3-oxazin-4-yl]-4-fluoranyl-phenyl]-5-cyano-pyridine-2-carboxamide'>0B6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygy OCA], [http://pdbe.org/5ygy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ygy RCSB], [http://www.ebi.ac.uk/pdbsum/5ygy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygy ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
| - | [ | + | == References == |
| - | [[ | + | <references/> |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
| - | [[Category: | + | [[Category: Memapsin 2]] |
[[Category: Ando, S]] | [[Category: Ando, S]] | ||
| - | [[Category: Koyabu, K]] | ||
| - | [[Category: Kurose, N]] | ||
| - | [[Category: Ogawa, M]] | ||
| - | [[Category: Mitsuoka, Y]] | ||
| - | [[Category: Masui, M]] | ||
| - | [[Category: Kusakabe, K]] | ||
| - | [[Category: Hiroyama, S]] | ||
[[Category: Borghys, H]] | [[Category: Borghys, H]] | ||
| - | [[Category: | + | [[Category: Dhuyvetter, D]] |
[[Category: Fuchino, K]] | [[Category: Fuchino, K]] | ||
| + | [[Category: Fukushima, T]] | ||
[[Category: Gijsen, H]] | [[Category: Gijsen, H]] | ||
| + | [[Category: Hiroyama, S]] | ||
| + | [[Category: Hosono, M]] | ||
| + | [[Category: Iso, Y]] | ||
[[Category: Ito, H]] | [[Category: Ito, H]] | ||
| - | [[Category: Unemura, C]] | ||
[[Category: Kido, Y]] | [[Category: Kido, Y]] | ||
| + | [[Category: Komano, K]] | ||
| + | [[Category: Koyabu, K]] | ||
| + | [[Category: Kurose, N]] | ||
| + | [[Category: Kusakabe, K]] | ||
| + | [[Category: Masui, M]] | ||
| + | [[Category: Mitsuoka, Y]] | ||
[[Category: Miyajima, H]] | [[Category: Miyajima, H]] | ||
| + | [[Category: Ogawa, M]] | ||
| + | [[Category: Ohnishi, S]] | ||
| + | [[Category: Sakaguchi, G]] | ||
| + | [[Category: Unemura, C]] | ||
| + | [[Category: Yamamoto, T]] | ||
| + | [[Category: Yamano, Y]] | ||
| + | [[Category: Yoshida, S]] | ||
| + | [[Category: Beta-site amyloid precursor protein cleaving enzyme 1]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
Revision as of 07:17, 23 May 2018
Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
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Categories: Memapsin 2 | Ando, S | Borghys, H | Dhuyvetter, D | Fuchino, K | Fukushima, T | Gijsen, H | Hiroyama, S | Hosono, M | Iso, Y | Ito, H | Kido, Y | Komano, K | Koyabu, K | Kurose, N | Kusakabe, K | Masui, M | Mitsuoka, Y | Miyajima, H | Ogawa, M | Ohnishi, S | Sakaguchi, G | Unemura, C | Yamamoto, T | Yamano, Y | Yoshida, S | Beta-site amyloid precursor protein cleaving enzyme 1 | Hydrolase-inhibitor complex
