6bbn
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a curved tubulin complex induced by the kinesin-13 Kif2A== | |
| - | + | <StructureSection load='6bbn' size='340' side='right' caption='[[6bbn]], [[Resolution|resolution]] 3.51Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bbn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbn OCA], [http://pdbe.org/6bbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bbn RCSB], [http://www.ebi.ac.uk/pdbsum/6bbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN]] Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.<ref>PMID:15843429</ref> <ref>PMID:17538014</ref> <ref>PMID:18411309</ref> [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Allingham, J S]] | ||
[[Category: Trofimova, D]] | [[Category: Trofimova, D]] | ||
| - | [[Category: | + | [[Category: Kif2a]] |
| + | [[Category: Kinesin]] | ||
| + | [[Category: Kinesin-13]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Tubulin]] | ||
Revision as of 07:20, 23 May 2018
Crystal structure of a curved tubulin complex induced by the kinesin-13 Kif2A
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Categories: Bos taurus | Allingham, J S | Trofimova, D | Kif2a | Kinesin | Kinesin-13 | Microtubule | Motor protein | Tubulin
