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6f6r
From Proteopedia
(Difference between revisions)
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<StructureSection load='6f6r' size='340' side='right' caption='[[6f6r]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6f6r' size='340' side='right' caption='[[6f6r]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F6R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F6R FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP1, IL1BC, IL1BCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6r OCA], [http://pdbe.org/6f6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f6r RCSB], [http://www.ebi.ac.uk/pdbsum/6f6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6r OCA], [http://pdbe.org/6f6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f6r RCSB], [http://www.ebi.ac.uk/pdbsum/6f6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6r ProSAT]</span></td></tr> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Caspase-1]] | [[Category: Caspase-1]] | ||
| + | [[Category: Human]] | ||
[[Category: Aubert, J]] | [[Category: Aubert, J]] | ||
[[Category: Aurelly, M]] | [[Category: Aurelly, M]] | ||
Current revision
Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide
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Categories: Caspase-1 | Human | Aubert, J | Aurelly, M | Bouix-Peter, C | Brethon, A | Chambon, S | Chantalat, L | Christin, O | Clary, L | Comino, C | Dumais, L | El-Bazbouz, G | Fournier, J F | Ghilini, A L | Harris, C S | Hennequin, L F | Isabet, T | Lardy, C | Luzy, A P | Mathieu, C | Mebrouk, K | Millois-Barbuis, C | Orfila, D | Pascau, J | Pierre, R | Reverse, K | Roche, D | Rodeschini, V | Talano, S | Thoreau, E | Hydrolase | Inflammatory disease | Nanomolar inhibitor | Sp3 hybridization
