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2chm
From Proteopedia
(Difference between revisions)
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| - | == | + | |
| + | ==Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5== | ||
<StructureSection load='2chm' size='340' side='right' caption='[[2chm]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='2chm' size='340' side='right' caption='[[2chm]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3P4:5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>3P4</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3P4:5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>3P4</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f0j|1f0j]], [[1jp1|1jp1]], [[1jp2|1jp2]], [[1ro6|1ro6]], [[1ro9|1ro9]], [[1ror|1ror]], [[1rkp|1rkp]], [[1t9r|1t9r]], [[1t9s|1t9s]], [[1tb5|1tb5]], [[1tbf|1tbf]], [[1udt|1udt]], [[1udu|1udu]], [[1uho|1uho]], [[1xlx|1xlx]], [[1xlz|1xlz]], [[1xm4|1xm4]], [[1xm6|1xm6]], [[1xmu|1xmu]], [[1xmy|1xmy]], [[1xn0|1xn0]], [[1xos|1xos]], [[1xot|1xot]], [[1xoz|1xoz]], [[1xp0|1xp0]], [[1y2h|1y2h]], [[1y2j|1y2j]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f0j|1f0j]], [[1jp1|1jp1]], [[1jp2|1jp2]], [[1ro6|1ro6]], [[1ro9|1ro9]], [[1ror|1ror]], [[1rkp|1rkp]], [[1t9r|1t9r]], [[1t9s|1t9s]], [[1tb5|1tb5]], [[1tbf|1tbf]], [[1udt|1udt]], [[1udu|1udu]], [[1uho|1uho]], [[1xlx|1xlx]], [[1xlz|1xlz]], [[1xm4|1xm4]], [[1xm6|1xm6]], [[1xmu|1xmu]], [[1xmy|1xmy]], [[1xn0|1xn0]], [[1xos|1xos]], [[1xot|1xot]], [[1xoz|1xoz]], [[1xp0|1xp0]], [[1y2h|1y2h]], [[1y2j|1y2j]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chm OCA], [http://pdbe.org/2chm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chm RCSB], [http://www.ebi.ac.uk/pdbsum/2chm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chm OCA], [http://pdbe.org/2chm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chm RCSB], [http://www.ebi.ac.uk/pdbsum/2chm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2chm ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chm_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chm_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Summerhill, N W]] | [[Category: Summerhill, N W]] | ||
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Camp]] | [[Category: Camp]] | ||
[[Category: Cgmp]] | [[Category: Cgmp]] | ||
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[[Category: Phosphodiesterase 5]] | [[Category: Phosphodiesterase 5]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| + | [[Category: Zinc]] | ||
Revision as of 08:02, 23 May 2018
Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5
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Categories: Human | Allerton, C M.N | Barber, C G | Beaumont, K C | Brown, D G | Cole, S M | Ellis, D | Lane, C A.L | Maw, G N | Mount, N M | Rawson, D J | Robinson, C M | Street, S D.A | Summerhill, N W | Allosteric enzyme | Alternative splicing | Camp | Cgmp | Cgmp-binding | Chimera | Hydrolase | Inhibitor | Magnesium | Metal-binding | Nucleotide-binding | Phosphodiesterase 5 | Phosphorylation | Zinc
