This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Fibroblast growth factor receptor
From Proteopedia
(Difference between revisions)
| Line 22: | Line 22: | ||
*FGFR1 | *FGFR1 | ||
| - | *''FGFR1 tyrosine kinase domain'' | + | *''FGFR1 tyrosine kinase domain residues 458-765'' |
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br /> | **[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br /> | ||
**[[4uwy]] – hFGFR1 TKD <br /> | **[[4uwy]] – hFGFR1 TKD <br /> | ||
| - | **[[4wun]], [[5am6]], [[5ew8]] – hFGFR1 TKD + inhibitor <br /> | + | **[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5ora]] – hFGFR1 TKD + inhibitor <br /> |
| - | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]] – hFGFR1 TKD (mutant) + inhibitor <br /> | + | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]] – hFGFR1 TKD (mutant) + inhibitor <br /> |
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | **[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | ||
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | **[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | ||
| Line 33: | Line 33: | ||
**[[3gql]] – hFGFR1 TKD (mutant) + substrate <br /> | **[[3gql]] – hFGFR1 TKD (mutant) + substrate <br /> | ||
| - | *''FGFR1 ligand-binding domain'' | + | *''FGFR1 ligand-binding domain D1 residues 35-208'' |
**[[2cr3]] – hFGFR1 LBD D1 - NMR<br /> | **[[2cr3]] – hFGFR1 LBD D1 - NMR<br /> | ||
**[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br /> | **[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br /> | ||
| - | *''FGFR1 complex with FGF'' | + | *''FGFR1 D1 complex with FGF'' |
| + | |||
| + | **[[5w59]] – hFGFR1 LBD D1 + FGF9<br /> | ||
| + | |||
| + | *''FGFR1 D2,D3 residues 142-365 complex with FGF'' | ||
**[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br /> | **[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br /> | ||
| Line 44: | Line 48: | ||
**[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br /> | **[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br /> | ||
**[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br /> | **[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br /> | ||
| + | **[[5w21]] – hFGFR1 LBD D2,D3 + hFGF23 + klotho <br /> | ||
*FGFR2 | *FGFR2 | ||
| Line 92: | Line 97: | ||
**[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | **[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | ||
**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br /> | **[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br /> | ||
| - | **[[5jkg]] – hFGFR4 TKD + inhibitor<br /> | + | **[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br /> |
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | **[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | ||
Revision as of 10:04, 24 May 2018
| |||||||||||
3D structures of fibroblast growth factor receptor
Updated on 24-May-2018
References
- ↑ Coutts JC, Gallagher JT. Receptors for fibroblast growth factors. Immunol Cell Biol. 1995 Dec;73(6):584-9. PMID:8713482 doi:http://dx.doi.org/10.1038/icb.1995.92
- ↑ Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, Mack ML, Kaitila I, Loughlin J, Munnich A, Sykes B, Bonaventure J, Francomano CA. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet. 1998 Sep;63(3):711-6. PMID:9718331 doi:http://dx.doi.org/10.1086/302000
- ↑ Intini D, Baldini L, Fabris S, Lombardi L, Ciceri G, Maiolo AT, Neri A. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol. 2001 Aug;114(2):362-4. PMID:11529856
- ↑ Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995 Dec;11(4):462-4. PMID:7493034 doi:http://dx.doi.org/10.1038/ng1295-462
