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Fructose-1,6-bisphosphatase
From Proteopedia
(Difference between revisions)
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**[[1spi]] - FBP - spinach<br /> | **[[1spi]] - FBP - spinach<br /> | ||
**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br /> | **[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br /> | ||
| + | **[[5k54]] – hFBP (mutant)<br /> | ||
**[[5iz1]] - FBP - moss<br /> | **[[5iz1]] - FBP - moss<br /> | ||
| + | **[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br /> | ||
| - | *FBP binary complexes | + | *FBP binary complexes with fructose-6-phosphate |
| + | |||
| + | **[[5et8]], [[5k56]] - hFBP + F6P<br /> | ||
| + | **[[5k55]] - hFBP (mutant) + F6P<br /> | ||
| + | **[[5fbp]] - pFBP + F6P<br /> | ||
| + | **[[1rdx]] - pFBP (mutant) + F6P<br /> | ||
| + | **[[2r8t]] - EcFBP GlpX + F6P<br /> | ||
| + | **[[3d1r]] - EcFBP GlpX (mutant) + F6P<br /> | ||
| + | |||
| + | *FBP other binary complexes | ||
**[[1fta]] – hFBP + AMP <br /> | **[[1fta]] – hFBP + AMP <br /> | ||
| Line 40: | Line 51: | ||
**[[3ifa]] - hFBP (mutant) + AMP<br /> | **[[3ifa]] - hFBP (mutant) + AMP<br /> | ||
**[[4he0]] - hFBP + phosphate<br /> | **[[4he0]] - hFBP + phosphate<br /> | ||
| - | **[[ | + | **[[5djk]], [[5djj]] - MtFBP + phosphate<br /> |
| + | **[[5djg]] - MtFBP + ADP derivative<br /> | ||
**[[1fpk]] – pFBP + Tl<br /> | **[[1fpk]] – pFBP + Tl<br /> | ||
**[[4fbp]] - pFBP + AMP <br /> | **[[4fbp]] - pFBP + AMP <br /> | ||
**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br /> | **[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br /> | ||
| - | **[[5fbp]] - pFBP + F6P<br /> | ||
| - | **[[1rdx]] - pFBP (mutant) + F6P<br /> | ||
**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br /> | **[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br /> | ||
**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br /> | **[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br /> | ||
| Line 52: | Line 62: | ||
**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br /> | **[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br /> | ||
**[[2gq1]] – EcFBP + sulfate <br /> | **[[2gq1]] – EcFBP + sulfate <br /> | ||
| - | **[[2r8t]] - EcFBP GlpX + F6P<br /> | ||
**[[3big]] - EcFBP GlpX (mutant) + phosphate<br /> | **[[3big]] - EcFBP GlpX (mutant) + phosphate<br /> | ||
| - | **[[ | + | **[[5oey]] - FBP + phosphate – ''Leishmania major''<br /> |
*FBP ternary complexes | *FBP ternary complexes | ||
| Line 72: | Line 81: | ||
**[[2qvr]] - EcFBP + citrate + F6-di-P<br /> | **[[2qvr]] - EcFBP + citrate + F6-di-P<br /> | ||
**[[2ox3]] - EcFBP + PEP + F6P<br /> | **[[2ox3]] - EcFBP + PEP + F6P<br /> | ||
| + | **[[6ayu]], [[6ayv]] - MtFBP (mutant) + malonate + F6P <br /> | ||
| + | **[[5dji]], [[5djh]] - MtFBP + phosphate + AMP<br /> | ||
*FBP quaternary complexes | *FBP quaternary complexes | ||
Revision as of 09:38, 28 May 2018
| |||||||||||
3D Structures of Fructose-1,6-bisphosphatase
Updated on 28-May-2018
References
- ↑ Zhang Y, Liang JY, Lipscomb WN. Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. PMID:8382485
- ↑ Storey KB. Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1115-24. PMID:9505421
- ↑ Depre C, Veitch K, Hue L. Role of fructose 2,6-bisphosphate in the control of glycolysis. Stimulation of glycogen synthesis by lactate in the isolated working rat heart. Acta Cardiol. 1993;48(1):147-64. PMID:8447185
- ↑ van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes. 2006 Jun;55(6):1747-54. PMID:16731838 doi:http://dx.doi.org/10.2337/db05-1443
- ↑ van Poelje PD, Potter SC, Erion MD. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. PMID:21484576 doi:http://dx.doi.org/10.1007/978-3-642-17214-4_12
- ↑ Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T. Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1004-7. Epub 2009 Dec 21. PMID:20045638 doi:10.1016/j.bmcl.2009.12.056
