Galactosidase

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Line 42: Line 42:
**[[4xpo]] - PsBgal – ''Pedobacter saltans'' <br />
**[[4xpo]] - PsBgal – ''Pedobacter saltans'' <br />
**[[4xpr]] - PsAgal (mutant)<br />
**[[4xpr]] - PsAgal (mutant)<br />
 +
**[[6f4c]] - Agal – ''Nicotiana benthamiana''<br />
*''α-galactosidase binary complex''
*''α-galactosidase binary complex''
Line 70: Line 71:
**[[3j7h]] – EcBgal – cryo EM<br />
**[[3j7h]] – EcBgal – cryo EM<br />
**[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br />
**[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br />
-
**[[1yq2]] - Bgal (mutant) – Arthrobacter<br />
+
**[[6etz]] - ArBgal – ''Arthrobacter''<br />
 +
**[[1yq2]] - ArBgal (mutant)<br />
**[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br />
**[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br />
**[[1uwq]], [[1gow]] – SsBgal<br />
**[[1uwq]], [[1gow]] – SsBgal<br />
Line 83: Line 85:
**[[4cu9]] – SpBgal carbohydrate-binding module II residues 1822-1998 <br />
**[[4cu9]] – SpBgal carbohydrate-binding module II residues 1822-1998 <br />
**[[4cua]] – SpBgal carbohydrate-binding module I residues 1463-1645 <br />
**[[4cua]] – SpBgal carbohydrate-binding module I residues 1463-1645 <br />
-
**[[4uoq]] - BaBgal (mutant) – ''Bifidobacterium animalis''<br />
+
**[[5xb7]] - BaBgal – ''Bifidobacterium animalis''<br />
 +
**[[4uoq]] - BaBgal (mutant) <br />
 +
**[[5vym]] - Bgal – ''Bifidobacterium adolescentis''<br />
 +
**[[5nav]], [[5naq]] - Bgal – ''Lactobacillus plantarum''<br />
**[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br />
**[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br />
**[[5dfa]] - GsBgal (mutant) <br />
**[[5dfa]] - GsBgal (mutant) <br />
Line 110: Line 115:
**[[4ucf]], [[4uzs]] - BbBgal + galactose <br />
**[[4ucf]], [[4uzs]] - BbBgal + galactose <br />
**[[5ldr]] - ParBgal + galactose <br />
**[[5ldr]] - ParBgal + galactose <br />
 +
**[[6eon]] - BtBgal + galactose <br />
*''β-Galactosidase other complexes''
*''β-Galactosidase other complexes''
Line 143: Line 149:
*3,6-anhydro-α-L-galactosidase
*3,6-anhydro-α-L-galactosidase
-
**[[3p2n]] – AAgal – ''Zobellia galactanivorans''<br />
+
**[[3p2n]], [[5opq]] – AAgal – ''Zobellia galactanivorans''<br />
**[[4ak5]] – BpAAgal – ''Bacterioides plebeius''<br />
**[[4ak5]] – BpAAgal – ''Bacterioides plebeius''<br />
**[[4ak6]] – BpAAgal (mutant)<br />
**[[4ak6]] – BpAAgal (mutant)<br />

Revision as of 08:05, 29 May 2018

Glycosylated beta-galactosidase complex with galactose (PDB entry 3w5g)

Drag the structure with the mouse to rotate

3D Structures of Galactosidase

Updated on 29-May-2018

References

  1. Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
  2. Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
  3. Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
  4. Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
  5. Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416


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Michal Harel, Alexander Berchansky

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