5nrs

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'''Unreleased structure'''
 
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The entry 5nrs is ON HOLD until Paper Publication
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==Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine==
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<StructureSection load='5nrs' size='340' side='right' caption='[[5nrs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Rondelet, G., Wouters, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nrs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NRS FirstGlance]. <br>
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Description: Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=962:(2~{S})-1-[2-hydroxyethyl-[(2~{S})-2-oxidanylpropyl]amino]propan-2-ol'>962</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nrs OCA], [http://pdbe.org/5nrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nrs RCSB], [http://www.ebi.ac.uk/pdbsum/5nrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nrs ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Rondelet, G]]
[[Category: Wouters, J]]
[[Category: Wouters, J]]
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[[Category: Rondelet, G]]
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[[Category: Beta barrel]]
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[[Category: Dnmt3b pwwp domain]]
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[[Category: Histone binding]]
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[[Category: Ligand]]
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[[Category: Transferase]]

Revision as of 05:24, 30 May 2018

Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine

5nrs, resolution 2.30Å

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