5o0y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==TLK2 kinase domain from human== | |
| - | + | <StructureSection load='5o0y' size='340' side='right' caption='[[5o0y]], [[Resolution|resolution]] 2.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5o0y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O0Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o0y OCA], [http://pdbe.org/5o0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o0y RCSB], [http://www.ebi.ac.uk/pdbsum/5o0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o0y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TLK2_HUMAN TLK2_HUMAN]] Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.<ref>PMID:10523312</ref> <ref>PMID:11470414</ref> <ref>PMID:12660173</ref> <ref>PMID:12955071</ref> <ref>PMID:20016786</ref> <ref>PMID:22354037</ref> <ref>PMID:9427565</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Montoya, G]] | ||
| + | [[Category: Mortuza, G B]] | ||
| + | [[Category: Atpg]] | ||
| + | [[Category: Chromatin remodelling]] | ||
| + | [[Category: Dna replication]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:26, 30 May 2018
TLK2 kinase domain from human
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