Mutations in BRCA1/BARD1 RING-domain heterodimer

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</jmolLink>
</jmolLink>
</jmol> between the two states.
</jmol> between the two states.
-
*<scene name='75/751104/C39r/1'>Mutation C39R:</scene>
+
*<scene name='75/751104/C39r/2'>Mutation C39R:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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</jmolLink>
</jmolLink>
</jmol> between the two states. This mutation causes missing of S-Zn bond.
</jmol> between the two states. This mutation causes missing of S-Zn bond.
-
*<scene name='75/751104/H41r/5'>Mutation H41R:</scene>
+
*<scene name='75/751104/H41r/6'>Mutation H41R:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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</jmolLink>
</jmolLink>
</jmol> between the two states. This mutation causes missing of N-Zn bond.
</jmol> between the two states. This mutation causes missing of N-Zn bond.
-
*<scene name='75/751104/C44s/3'>Mutation C44S:</scene>
+
*<scene name='75/751104/C44s/4'>Mutation C44S:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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</jmolLink>
</jmolLink>
</jmol> between the two states. This mutation causes missing of S-Zn bond.
</jmol> between the two states. This mutation causes missing of S-Zn bond.
-
*<scene name='75/751104/C44y/3'>Mutation C44Y:</scene>
+
*<scene name='75/751104/C44y/4'>Mutation C44Y:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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=== Very severe pathogenic mutation ===
=== Very severe pathogenic mutation ===
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*<scene name='75/751104/C61g/3'>Mutation C61G:</scene>
+
*<scene name='75/751104/C61g/4'>Mutation C61G:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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==Benign mutations==
==Benign mutations==
-
*<scene name='75/751104/Cv/26'>Mutation K45Q:</scene>
+
*<scene name='75/751104/Cv/29'>Mutation K45Q:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
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</jmolLink>
</jmolLink>
</jmol> between the two states.
</jmol> between the two states.
-
*<scene name='75/751104/Cv/27'>Mutation D67Y:</scene>
+
*<scene name='75/751104/Cv/30'>Mutation D67Y:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>

Revision as of 11:34, 31 May 2018

PDB ID 1jm71.pdb

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References

  1. ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman

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