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Sandbox 7726
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== Disease == | == Disease == | ||
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| + | This disease is primarily caused by the polyglutamine expansion in the ATXN1 protein. However, other factors are also required for the development of SCA1 neuropathology, including phosphorylation of Ser776 and nuclear localization. | ||
== Relevance == | == Relevance == | ||
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| + | This is a rare neurodegenerative disease, only hitting 1 out 2 out of 100,000 people, and there is no therapeutic agent for this illness yet. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 06:40, 5 June 2018
Protein-protein interaction between Ataxin-1 and Capicua
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References
- ↑ Kim E, Lu HC, Zoghbi HY, Song JJ. Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua. Genes Dev. 2013 Mar 15;27(6):590-5. doi: 10.1101/gad.212068.112. PMID:23512657 doi:http://dx.doi.org/10.1101/gad.212068.112
