2ix7

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|PDB= 2ix7 |SIZE=350|CAPTION= <scene name='initialview01'>2ix7</scene>, resolution 2.50&Aring;
|PDB= 2ix7 |SIZE=350|CAPTION= <scene name='initialview01'>2ix7</scene>, resolution 2.50&Aring;
|SITE= <scene name='pdbsite=AC1:CYS+Binding+Site+For+Chain+C'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:CYS+Binding+Site+For+Chain+C'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>
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|LIGAND= <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ix7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix7 OCA], [http://www.ebi.ac.uk/pdbsum/2ix7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ix7 RCSB]</span>
}}
}}
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[[Category: Mui, S.]]
[[Category: Mui, S.]]
[[Category: Trybus, K M.]]
[[Category: Trybus, K M.]]
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[[Category: CYS]]
 
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[[Category: SO4]]
 
[[Category: acetylation]]
[[Category: acetylation]]
[[Category: actin-binding]]
[[Category: actin-binding]]
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:34:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:56 2008''

Revision as of 00:49, 31 March 2008

Image:2ix7.gif


PDB ID 2ix7

Drag the structure with the mouse to rotate
, resolution 2.50Å
Sites:
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V


Overview

A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR). Variable residues in the IQ motif play a critical role in determining the precise structure of the bound CaM, such that even the consensus residues of different motifs show unique interactions with CaM. This complex serves as a model for the lever arm region of many classes of unconventional myosins, as well as other IQ motif-containing proteins such as neuromodulin and IQGAPs.

About this Structure

2IX7 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:17151196

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