5xpp

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m (Protected "5xpp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xpp is ON HOLD until Paper Publication
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==Crystal structure of VDR-LBD complexed with 25RS-(Hydroxyphenyl)-2-methylidene-19,26,27-trinor-1,25-dihydroxyvitamin D3==
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<StructureSection load='5xpp' size='340' side='right' caption='[[5xpp]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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Authors: Kato, A., Itoh, T., Yamamoto, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xpp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XPP FirstGlance]. <br>
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Description: Crystal structure of VDR-LBD complexed with 25RS-(Hydroxyphenyl)-2-methylidene-19,26,27-trinor-1,25-dihydroxyvitamin D3
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BF:(1~{R},3~{R})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-1-[(2~{R},6~{R})-6-(4-hydroxyphenyl)-6-oxidanyl-hexan-2-yl]-7~{a}-methyl-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol'>8BF</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xpp OCA], [http://pdbe.org/5xpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xpp RCSB], [http://www.ebi.ac.uk/pdbsum/5xpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xpp ProSAT]</span></td></tr>
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[[Category: Yamamoto, K]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Itoh, T]]
[[Category: Itoh, T]]
[[Category: Kato, A]]
[[Category: Kato, A]]
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[[Category: Yamamoto, K]]
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[[Category: Co-factor]]
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[[Category: Rxr]]
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[[Category: Transcription]]
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[[Category: Vdr]]
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[[Category: Vdre]]
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[[Category: Vitamin d3]]

Revision as of 05:51, 6 June 2018

Crystal structure of VDR-LBD complexed with 25RS-(Hydroxyphenyl)-2-methylidene-19,26,27-trinor-1,25-dihydroxyvitamin D3

5xpp, resolution 2.85Å

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