5xty
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of 11S allergen from Cocos nucifera L.== | |
| + | <StructureSection load='5xty' size='340' side='right' caption='[[5xty]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5xty]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cocos_nucifera Cocos nucifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XTY FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xty OCA], [http://pdbe.org/5xty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xty RCSB], [http://www.ebi.ac.uk/pdbsum/5xty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xty ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Allergy is an abnormal immune response against an innocuous target. Food allergy is an adverse reaction caused by common foods most well-known being those involving peanuts. Apart from mono sensitized food allergy, cross-reactivity with other food allergens is also commonly observed. To understand the phenomenon of cross-reactivity related to immune response, three dimensional structures of the allergens and their antigenic epitopes has to be analysed in detail. The X-ray crystal structure of Cocosin, a common 11S food allergen from coconut, has been determined at 2.2A resolution using molecular replacement technique. The monomer of 52kDa is composed of two beta-jelly roll domains, one with acidic and the other with basic character. The structure shows hexameric association with two trimers facing each other. Though the overall structure of Cocosin is similar to other 11S allergens, the occurrence of experimentally determined epitopes of the peanut allergen Ara h 3 at flexible as well as variable regions could be the reason for the clinically reported result of cross-reactivity that the peanut allergic patients are not sensitized with coconut allergen. | ||
| - | + | Crystal structure determination and analysis of 11S coconut allergen: Cocosin.,Vajravijayan S, Nandhagopal N, Gunasekaran K Mol Immunol. 2017 Dec;92:132-135. doi: 10.1016/j.molimm.2017.10.018. Epub 2017, Oct 31. PMID:29096167<ref>PMID:29096167</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5xty" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cocos nucifera]] | ||
| + | [[Category: Gunasekaran, K]] | ||
| + | [[Category: Nandhagopal, N]] | ||
| + | [[Category: Vajravijayan, S]] | ||
| + | [[Category: 11s allergen]] | ||
| + | [[Category: Allergen]] | ||
| + | [[Category: Coconut]] | ||
| + | [[Category: Cocosin]] | ||
| + | [[Category: Twinning]] | ||
Revision as of 05:51, 6 June 2018
Crystal Structure of 11S allergen from Cocos nucifera L.
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