5ygu

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m (Protected "5ygu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ygu is ON HOLD
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==Crystal structure of Escherichia coli (strain K12) mRNA Decapping Complex RppH-DapF==
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<StructureSection load='5ygu' size='340' side='right' caption='[[5ygu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ygu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YGU FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ygu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygu OCA], [http://pdbe.org/5ygu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ygu RCSB], [http://www.ebi.ac.uk/pdbsum/5ygu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DAPF_ECOLI DAPF_ECOLI]] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration.<ref>PMID:6378903</ref> <ref>PMID:3031013</ref> <ref>PMID:3042781</ref> [[http://www.uniprot.org/uniprot/RPPH_ECOLI RPPH_ECOLI]] Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.<ref>PMID:10760174</ref> <ref>PMID:18202662</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Diaminopimelate epimerase]]
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[[Category: Guan, Z Y]]
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[[Category: Wang, Q]]
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[[Category: Yin, P]]
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[[Category: Zhang, D L]]
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[[Category: Zou, T T]]
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[[Category: Decapping]]
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[[Category: Hydrolase]]
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[[Category: Isomerase-hydrolase complex]]
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[[Category: Rpph-dapf]]

Revision as of 05:53, 6 June 2018

Crystal structure of Escherichia coli (strain K12) mRNA Decapping Complex RppH-DapF

5ygu, resolution 2.30Å

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