5z78
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of TIRR/53BP1 complex== | |
| - | + | <StructureSection load='5z78' size='340' side='right' caption='[[5z78]], [[Resolution|resolution]] 1.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5z78]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z78 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z78 OCA], [http://pdbe.org/5z78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z78 RCSB], [http://www.ebi.ac.uk/pdbsum/5z78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z78 ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Dai, Y | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIRR_MOUSE TIRR_MOUSE]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA.[UniProtKB:Q9BRJ7] [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dai, Y X]] | ||
[[Category: Shan, S]] | [[Category: Shan, S]] | ||
| + | [[Category: Dna repair protein]] | ||
| + | [[Category: Transcription-protein binding complex]] | ||
Revision as of 05:54, 6 June 2018
Structure of TIRR/53BP1 complex
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