6co1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human TIRR in complex with 53BP1 Tudor domains== | |
| - | + | <StructureSection load='6co1' size='340' side='right' caption='[[6co1]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6co1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co1 OCA], [http://pdbe.org/6co1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co1 RCSB], [http://www.ebi.ac.uk/pdbsum/6co1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co1 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref> [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Botuyan, M V]] | ||
| + | [[Category: Cui, G]] | ||
| + | [[Category: Mer, G]] | ||
| + | [[Category: Dna damage response]] | ||
| + | [[Category: Dna damage signaling]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Nudt16l1]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Tirr]] | ||
Revision as of 05:56, 6 June 2018
Structure of human TIRR in complex with 53BP1 Tudor domains
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