6d0l
From Proteopedia
(Difference between revisions)
m (Protected "6d0l" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human TIRR== | |
| - | + | <StructureSection load='6d0l' size='340' side='right' caption='[[6d0l]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d0l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6co1|6co1]], [[6co2|6co2]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0l OCA], [http://pdbe.org/6d0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d0l RCSB], [http://www.ebi.ac.uk/pdbsum/6d0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0l ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Botuyan, M V]] | ||
| + | [[Category: Cui, G]] | ||
| + | [[Category: Mer, G]] | ||
| + | [[Category: Dna damage response]] | ||
| + | [[Category: Dna double-strand break repair]] | ||
| + | [[Category: Nudt16l1]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Rna binding]] | ||
Revision as of 05:57, 6 June 2018
Structure of human TIRR
| |||||||||||
