2j46
From Proteopedia
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|PDB= 2j46 |SIZE=350|CAPTION= <scene name='initialview01'>2j46</scene>, resolution 1.135Å | |PDB= 2j46 |SIZE=350|CAPTION= <scene name='initialview01'>2j46</scene>, resolution 1.135Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j46 OCA], [http://www.ebi.ac.uk/pdbsum/2j46 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j46 RCSB]</span> | ||
}} | }} | ||
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[[Category: Freymann, D M.]] | [[Category: Freymann, D M.]] | ||
[[Category: Ramirez, U D.]] | [[Category: Ramirez, U D.]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: MN]] | ||
| - | [[Category: MRD]] | ||
[[Category: ffh]] | [[Category: ffh]] | ||
[[Category: gtp-binding]] | [[Category: gtp-binding]] | ||
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[[Category: water]] | [[Category: water]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:41 2008'' |
Revision as of 00:52, 31 March 2008
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| , resolution 1.135Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION
Overview
Two new structures of the SRP GTPase Ffh have been determined at 1.1 A resolution and provide the basis for comparative examination of the extensive water structure of the apo conformation of these GTPases. A set of well defined water-binding positions have been identified in the active site of the two-domain ;NG' GTPase, as well as at two functionally important interfaces. The water hydrogen-bonding network accommodates alternate conformations of the protein side chains by undergoing local rearrangements and, in one case, illustrates binding of a solute molecule within the active site by displacement of water molecules without further disruption of the water-interaction network. A subset of the water positions are well defined in several lower resolution structures, including those of different nucleotide-binding states; these appear to function in maintaining the protein structure. Consistent arrangements of surface water between three different ultrahigh-resolution structures provide a framework for beginning to understand how local water structure contributes to protein-ligand and protein-protein binding in the SRP GTPases.
About this Structure
2J46 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:17139088
Page seeded by OCA on Mon Mar 31 03:52:41 2008
