2j4a
From Proteopedia
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|PDB= 2j4a |SIZE=350|CAPTION= <scene name='initialview01'>2j4a</scene>, resolution 2.2Å | |PDB= 2j4a |SIZE=350|CAPTION= <scene name='initialview01'>2j4a</scene>, resolution 2.2Å | ||
|SITE= <scene name='pdbsite=AC1:Oef+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Oef+Binding+Site+For+Chain+A'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=OEF:3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID'>OEF</scene> | + | |LIGAND= <scene name='pdbligand=OEF:3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC+ACID'>OEF</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bsx|1BSX]], [[1n46|1N46]], [[1nax|1NAX]], [[1nq0|1NQ0]], [[1nq1|1NQ1]], [[1nq2|1NQ2]], [[1nuo|1NUO]], [[1q4x|1Q4X]], [[1r6g|1R6G]], [[1xzx|1XZX]], [[1y0x|1Y0X]], [[2h6w|2H6W]], [[2nll|2NLL]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4a OCA], [http://www.ebi.ac.uk/pdbsum/2j4a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j4a RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats. | A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats. | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Thyroid hormone resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190160 190160]], Thyroid hormone resistance, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190160 190160]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Farnegardh, M.]] | [[Category: Farnegardh, M.]] | ||
| - | [[Category: OEF]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: deafness]] | [[Category: deafness]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:44 2008'' |
Revision as of 00:52, 31 March 2008
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| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Related: | 1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2H6W, 2NLL
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN THYROID HORMONE RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH KB131084
Overview
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
About this Structure
2J4A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor., Koehler K, Gordon S, Brandt P, Carlsson B, Backsbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Farnegardh M, Rehnmark S, Malm J, J Med Chem. 2006 Nov 16;49(23):6635-7. PMID:17154490
Page seeded by OCA on Mon Mar 31 03:52:44 2008
