Growth differentiation factor

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Line 15: Line 15:
*GDF-2
*GDF-2
-
**[[1zkz]], [[4mpl]] – hGDF residues 320-493 – human <br />
+
**[[1zkz]], [[4mpl]], [[5i05]] – hGDF residues 320-493 – human <br />
**[[4fao]] – hGDF residues 320-493 + serine/threonine-protein kinase receptor + activin receptor<br />
**[[4fao]] – hGDF residues 320-493 + serine/threonine-protein kinase receptor + activin receptor<br />
 +
**[[5hzw]] – hGDF residues 320-493 + MBP/endoglin <br />
**[[4ycg]], [[4yci]] – mGDF residues 23-318 + hGDF residues 320-493 - mouse<br />
**[[4ycg]], [[4yci]] – mGDF residues 23-318 + hGDF residues 320-493 - mouse<br />
Line 31: Line 32:
**[[3hh2]] – mGDF + follistatin <br />
**[[3hh2]] – mGDF + follistatin <br />
**[[3sek]] – mGDF + follistatin-related protein <br />
**[[3sek]] – mGDF + follistatin-related protein <br />
-
**[[5f3hf]], [[5f3b]] – hGDF + antibody <br />
+
**[[5nsx]], [[5ntu]] – hGDF (mutant) <br />
 +
**[[5f3h]], [[5f3b]] – hGDF + antibody <br />
*GDF-11
*GDF-11
Line 37: Line 39:
**[[5uhm]], [[5e4g]] – hGDF <br />
**[[5uhm]], [[5e4g]] – hGDF <br />
**[[5jhw]] – hGDF + follistatin <br />
**[[5jhw]] – hGDF + follistatin <br />
 +
 +
*GDF-15
 +
 +
**[[5vz3]], [[5vt2]] – hGDF <br />
 +
**[[5vz4]] – hGDF + GDNF family receptor a-like <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:19, 6 June 2018

Structure of growth differentiation factor GDF-5 (green and aqua) complex with bone morphogenetic receptor (pink and olive) (PDB entry 3evs)

Drag the structure with the mouse to rotate

3D structures of growth differentiation factor

Updated on 06-June-2018

References

  1. Jin L, Li X. Growth differentiation factor 5 regulation in bone regeneration. Curr Pharm Des. 2013;19(19):3364-73. PMID:23432680
  2. Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM, Hurley BF. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics. 1999 Dec 1;62(2):203-7. PMID:10610713 doi:http://dx.doi.org/10.1006/geno.1999.5984
  3. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015. PMID:23663781 doi:http://dx.doi.org/10.1016/j.cell.2013.04.015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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