5n9b

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'''Unreleased structure'''
 
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The entry 5n9b is ON HOLD until Paper Publication
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==Crystal Structure of unliganded human IL-17RA==
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<StructureSection load='5n9b' size='340' side='right' caption='[[5n9b]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Rondeau, J.-M., Goepfert, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5n9b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N9B FirstGlance]. <br>
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Description: Crystal Structure of unliganded human IL-17RA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5n92|5n92]]</td></tr>
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[[Category: Rondeau, J.-M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n9b OCA], [http://pdbe.org/5n9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n9b RCSB], [http://www.ebi.ac.uk/pdbsum/5n9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n9b ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:[http://omim.org/entry/613953 613953]]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.<ref>PMID:21993848</ref> <ref>PMID:19838198</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Goepfert, A]]
[[Category: Goepfert, A]]
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[[Category: Rondeau, J M]]
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[[Category: Fibronectin type iii]]
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[[Category: Signaling protein]]

Revision as of 07:27, 14 June 2018

Crystal Structure of unliganded human IL-17RA

5n9b, resolution 1.90Å

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