5o4s

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m (Protected "5o4s" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5o4s is ON HOLD until Paper Publication
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==Crystal structure of the human BRPF1 bromodomain in complex with BZ135==
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<StructureSection load='5o4s' size='340' side='right' caption='[[5o4s]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors: Zhu, J., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5o4s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O4S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O4S FirstGlance]. <br>
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Description: Crystal structure of the human BRPF1 bromodomain in complex with BZ135
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9KW:~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide'>9KW</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o4s OCA], [http://pdbe.org/5o4s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o4s RCSB], [http://www.ebi.ac.uk/pdbsum/5o4s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o4s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Caflisch, A]]
[[Category: Zhu, J]]
[[Category: Zhu, J]]
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[[Category: Caflisch, A]]
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[[Category: Dna binding protein]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]

Revision as of 07:29, 14 June 2018

Crystal structure of the human BRPF1 bromodomain in complex with BZ135

5o4s, resolution 1.75Å

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